Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development
Identifieur interne : 000070 ( France/Analysis ); précédent : 000069; suivant : 000071Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development
Auteurs : Kate L. Lowe [Royaume-Uni] ; Brenda A. Finney [Royaume-Uni] ; Carsten Deppermann [Allemagne] ; René H Gerling [Allemagne] ; Salomé L. Gazit [France] ; Jon Frampton ; Christopher Buckley [Royaume-Uni] ; Eric Camerer [France] ; Bernhard Nieswandt [Allemagne] ; Friedemann Kiefer [Allemagne] ; Steve P. Watson [Royaume-Uni]Source :
- Blood [ 0006-4971 ] ; 2015.
Abstract
Podoplanin and CLEC-2 critically drive the formation and integrity of developing cerebral blood vessels. Loss of cerebrovascular integrity is influenced by the loss of αIIb-mediated platelet aggregation and platelet secretion.
Url:
DOI: 10.1182/blood-2014-09-603803
PubMed: 25908104
PubMed Central: 4463737
Affiliations:
- Allemagne, France, Royaume-Uni
- Angleterre, Bavière, District de Basse-Franconie, District de Münster, Midlands de l'Ouest, Rhénanie-du-Nord-Westphalie, Île-de-France
- Birmingham, Münster, Paris, Wurtzbourg
- Université Paris-Descartes, Université de Birmingham
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000253
- to stream Pmc, to step Curation: 000253
- to stream Pmc, to step Checkpoint: 000F76
- to stream Ncbi, to step Merge: 007303
- to stream Ncbi, to step Curation: 007303
- to stream Ncbi, to step Checkpoint: 007303
- to stream Main, to step Merge: 001988
- to stream Main, to step Curation: 001985
- to stream Main, to step Exploration: 001985
- to stream France, to step Extraction: 000070
Links to Exploration step
PMC:4463737Le document en format XML
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Lowe</name><affiliation wicri:level="4"><nlm:aff id="aff1">Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region><settlement type="city">Birmingham</settlement></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Finney, Brenda A" sort="Finney, Brenda A" uniqKey="Finney B" first="Brenda A." last="Finney">Brenda A. 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Lowe</name><affiliation wicri:level="4"><nlm:aff id="aff1">Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region><settlement type="city">Birmingham</settlement></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Finney, Brenda A" sort="Finney, Brenda A" uniqKey="Finney B" first="Brenda A." last="Finney">Brenda A. Finney</name><affiliation wicri:level="4"><nlm:aff id="aff1">Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region><settlement type="city">Birmingham</settlement></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Deppermann, Carsten" sort="Deppermann, Carsten" uniqKey="Deppermann C" first="Carsten" last="Deppermann">Carsten Deppermann</name><affiliation wicri:level="3"><nlm:aff id="aff2">Department of Experimental Biomedicine, University of Würzburg, University Hospital and Rudolf Virchow Centre, Würzburg, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Experimental Biomedicine, University of Würzburg, University Hospital and Rudolf Virchow Centre, Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="H Gerling, Rene" sort="H Gerling, Rene" uniqKey="H Gerling R" first="René" last="H Gerling">René H Gerling</name><affiliation wicri:level="3"><nlm:aff id="aff3">Max-Planck-Institute for Molecular Biomedicine, Department Vascular Cell Biology, Münster, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max-Planck-Institute for Molecular Biomedicine, Department Vascular Cell Biology, Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Gazit, Salome L" sort="Gazit, Salome L" uniqKey="Gazit S" first="Salomé L." last="Gazit">Salomé L. Gazit</name><affiliation wicri:level="3"><nlm:aff id="aff4">INSERM U970, Paris Cardiovascular Research Centre, Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U970, Paris Cardiovascular Research Centre, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5">Université Paris-Descartes, Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Frampton, Jon" sort="Frampton, Jon" uniqKey="Frampton J" first="Jon" last="Frampton">Jon Frampton</name><affiliation><nlm:aff wicri:cut=", and" id="aff6">School of Immunity and Infection</nlm:aff></affiliation></author><author><name sortKey="Buckley, Christopher" sort="Buckley, Christopher" uniqKey="Buckley C" first="Christopher" last="Buckley">Christopher Buckley</name><affiliation wicri:level="4"><nlm:aff id="aff7">Rheumatology Research Group, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Rheumatology Research Group, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region><settlement type="city">Birmingham</settlement></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Camerer, Eric" sort="Camerer, Eric" uniqKey="Camerer E" first="Eric" last="Camerer">Eric Camerer</name><affiliation wicri:level="3"><nlm:aff id="aff4">INSERM U970, Paris Cardiovascular Research Centre, Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U970, Paris Cardiovascular Research Centre, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5">Université Paris-Descartes, Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Nieswandt, Bernhard" sort="Nieswandt, Bernhard" uniqKey="Nieswandt B" first="Bernhard" last="Nieswandt">Bernhard Nieswandt</name><affiliation wicri:level="3"><nlm:aff id="aff2">Department of Experimental Biomedicine, University of Würzburg, University Hospital and Rudolf Virchow Centre, Würzburg, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Experimental Biomedicine, University of Würzburg, University Hospital and Rudolf Virchow Centre, Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Kiefer, Friedemann" sort="Kiefer, Friedemann" uniqKey="Kiefer F" first="Friedemann" last="Kiefer">Friedemann Kiefer</name><affiliation wicri:level="3"><nlm:aff id="aff3">Max-Planck-Institute for Molecular Biomedicine, Department Vascular Cell Biology, Münster, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max-Planck-Institute for Molecular Biomedicine, Department Vascular Cell Biology, Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Watson, Steve P" sort="Watson, Steve P" uniqKey="Watson S" first="Steve P." last="Watson">Steve P. Watson</name><affiliation wicri:level="4"><nlm:aff id="aff1">Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region><settlement type="city">Birmingham</settlement></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><idno type="eISSN">1528-0020</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Key Points</title><p><list list-type="bullet"><list-item><p>Podoplanin and CLEC-2 critically drive the formation and integrity of developing cerebral blood vessels.</p></list-item><list-item><p>Loss of cerebrovascular integrity is influenced by the loss of αIIb-mediated platelet aggregation and platelet secretion.</p></list-item></list></p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>France</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Bavière</li><li>District de Basse-Franconie</li><li>District de Münster</li><li>Midlands de l'Ouest</li><li>Rhénanie-du-Nord-Westphalie</li><li>Île-de-France</li></region><settlement><li>Birmingham</li><li>Münster</li><li>Paris</li><li>Wurtzbourg</li></settlement><orgName><li>Université Paris-Descartes</li><li>Université de Birmingham</li></orgName></list><tree><noCountry><name sortKey="Frampton, Jon" sort="Frampton, Jon" uniqKey="Frampton J" first="Jon" last="Frampton">Jon Frampton</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Lowe, Kate L" sort="Lowe, Kate L" uniqKey="Lowe K" first="Kate L." last="Lowe">Kate L. Lowe</name></region><name sortKey="Buckley, Christopher" sort="Buckley, Christopher" uniqKey="Buckley C" first="Christopher" last="Buckley">Christopher Buckley</name><name sortKey="Finney, Brenda A" sort="Finney, Brenda A" uniqKey="Finney B" first="Brenda A." last="Finney">Brenda A. Finney</name><name sortKey="Watson, Steve P" sort="Watson, Steve P" uniqKey="Watson S" first="Steve P." last="Watson">Steve P. Watson</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Deppermann, Carsten" sort="Deppermann, Carsten" uniqKey="Deppermann C" first="Carsten" last="Deppermann">Carsten Deppermann</name></region><name sortKey="H Gerling, Rene" sort="H Gerling, Rene" uniqKey="H Gerling R" first="René" last="H Gerling">René H Gerling</name><name sortKey="Kiefer, Friedemann" sort="Kiefer, Friedemann" uniqKey="Kiefer F" first="Friedemann" last="Kiefer">Friedemann Kiefer</name><name sortKey="Nieswandt, Bernhard" sort="Nieswandt, Bernhard" uniqKey="Nieswandt B" first="Bernhard" last="Nieswandt">Bernhard Nieswandt</name></country><country name="France"><region name="Île-de-France"><name sortKey="Gazit, Salome L" sort="Gazit, Salome L" uniqKey="Gazit S" first="Salomé L." last="Gazit">Salomé L. Gazit</name></region><name sortKey="Camerer, Eric" sort="Camerer, Eric" uniqKey="Camerer E" first="Eric" last="Camerer">Eric Camerer</name><name sortKey="Camerer, Eric" sort="Camerer, Eric" uniqKey="Camerer E" first="Eric" last="Camerer">Eric Camerer</name><name sortKey="Gazit, Salome L" sort="Gazit, Salome L" uniqKey="Gazit S" first="Salomé L." last="Gazit">Salomé L. Gazit</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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